2024 College Football Week 5 Picks and Odds | Top 25 College Football Betting Preview & Predictions

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This weekend, the top 25 college football teams will face off in four big games. The first game, at noon Eastern on ESPN, features Oklahoma State at Kansas State. While Oklahoma State has been struggling, Kansas State's strong rushing game and 3-0 start make them a good bet to win. The line favors Kansas State by 5 points, which is exactly what my database simulation predicts.

The next game, at 3:30 Eastern on the Peacock Network, is Louisville versus Notre Dame. I project Notre Dame to win by 11.5 points, which is in line with the current line of 6.5 to 7. Louisville has been impressive so far, but their lack of turnovers and inability to rush the ball may lead to a difficult road game.

The nighttime games, both at 7:30 Eastern, are Georgia at Alabama and Illinois at Penn State. In the biggest game of the season, Georgia is favored by 6 points, but my database simulation predicts an Alabama win. Georgia has struggled against Alabama in the past, and their offense has been suspect lately. The total for this game is around 48, which could be affected by the weather.

In the bonus game, Boise State will face off against Washington State at 10:30 Eastern. While not as highly ranked, this game has the potential to be exciting and could be a good opportunity for an upset.

These games offer a variety of betting opportunities, with some lines offering value and others not. It's important to do your research and consider multiple factors before making a bet.

College Football Week 5 brings us a handful of Top 25 matchups. Join Steve Merril as he takes a look at this weekend's best …