The Pittsburgh Steelers are heading back on the road this week for a showdown with the Indianapolis Colts. Unfortunately, despite their 3-0 start, the injuries are starting to pile up, which could make their Week 4 outing more of an uphill battle than it needs to be against a dysfunctional Colts offense.

The absences of OLB Alex Highsmith and TE MyCole Pruitt at Wednesday’s practice weren’t unexpected, as HC Mike Tomlin gave an update on Tuesday that both were likely to miss Week 4. However, RB Jaylen Warren missing practice is a bit more concerning. Tomlin pulled Warren from their Week 3 matchup after he appeared to be limping in the game, and he was set to undergo an MRI on Monday, though the results of that haven’t been made public.

Conversely, Najee Harris, who was spotted in a shoulder sling after Week 3, will be a full go.

Here’s a full breakdown of Steelers injury report for Wednesday, September 25 ahead of their Week 4 matchup with the Colts.

Steelers injury report: Wednesday, September 25

DNP: Jaylen Warren (knee), LB Alex Highsmith (groin), MyCole Pruitt (knee)

Limited: QB Russell Wilson (calf), LG Isaac Seumalo (pectoral), DeShon Elliott (quad)

Full: WR Roman Wilson (ankle), WR Van Jefferson (eye)

Rest days: LB T.J. Watt, RB Najee Harris, DT Can Heyward, DL Larry Ogunjobi