The Pittsburgh Steelers have held their second practice of the week in preparation for their Week 4 road trip to take on the Indianapolis Colts. Wednesday’s practice report was a particularly busy one, with several starters out, including LB Alex Highsmith and TE MyCole Pruitt, both of whom also missed Thursday’s practice and were unofficially announced as “out” in Mike Tomlin’s weekly press conference.

Highsmith out will put second-year OLB Nick Herbig in line for a significant uptick in snaps. In Week 3, Herbig managed a forced fumble and two sacks to help put a stamp on a dominant defensive win.

The name to watch approaching the weekend will be RB Jaylen Warren, who has now missed consecutive practices with a knee injury that popped up in Week 3’s win over the Los Angeles Chargers. RB/KR Cordarrelle Patterson would likely be in for an increase in snaps in his absence, should he miss Week 4 with the injury. Aaron Shampklin and Jonathan Ward also remain depth options for the team as possible promotions from the practice squad.

In the good news column, safety De’Shon Elliott was upgraded from a limited participant on Wednesday to a full participant on Thursday after being listed with a quad injury.

Here’s a full breakdown of Steelers injury report for Thursday, September 25 ahead of their Week 4 matchup with the Colts.

Steelers injury report: Thursday (Week 4)

DNP: Jaylen Warren (knee), LB Alex Highsmith (groin), TE MyCole Pruitt (knee)

Limited: QB Russell Wilson (calf), LG Isaac Seumalo (pectoral)

Full: WR Roman Wilson (ankle), WR Van Jefferson (eye), DeShon Elliott (quad)

Rest day: S Miles Killebrew, RB Cordarrelle Patterson, DT Cam Heyward

*Italics indicate a change in status from Wednesday’s practice report